Department of Surgery, CUHK Department of Surgery, CUHK


Dr CHEUNG Siu Tim    

Associate Professor



Cheung focuses on the investigation of molecular basis of human cancer, aim to improve treatment strategies and ultimately patient survival. The team has deciphered liver cancer expression profiles and metastasis associated genes. Continuation research included identification of potential therapeutic target, the novel growth factor granulin-epithelin precursor (GEP), and consolidated the roles on cancer growth, invasion, drug resistance, cancer stem cell properties and antibody targeted therapy.

Research Interest

  • Cancer Genomics
  • Novel Targeted Therapeutics
  • Drug Resistance

Selected Publications

  1. Fung SW, Cheung PF, Yip CW, Ng LW, Cheung TT, Chong CC, Lee C, Lai PB, Chan AW, Tsao GS, Wong CH, Chan SL, Lo KW, Cheung ST (correspondence). The ATP-binding cassette transporter ABCF1 is a hepatic oncofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma. Cancer Letters 2019;457:98-109.
  2. Cheung PF, Cheung TT, Yip CW, Ng LW, Fung SW, Lo CM, Fan ST, Cheung ST (correspondence). Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma. OncoTarget 2016; 7(16):21644-57
  3. Cheung PF, Yip CW, Ng LW, Wong CK, Cheung TT, Lo CM, Fan ST, Cheung ST (correspondence). Restoration of natural killer activity in hepatocellular carcinoma patients by treatment with antibody against granulin-epithelin precursor. OncoImmunology 2015; 4: e1016706.
  4. Wong NC, Cheung PF, Yip CW, Chan KF, Ng IO, Fan ST, Cheung ST (correspondence). Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents. Molecular Cancer Therapeutics 2014; 13: 3001-3012.
  5. Yip CW, Cheung PF, Leung IC, Wong NC, Cheng CK, Fan ST, Cheung ST (correspondence). Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells. Carcinogenesis 2014; 35: 2485-2494.
  6. Cheung PF, Yip CW, Wong NC, Fong DY, Ng LW, Wan AM, Wong CK, Cheung TT, Ng IO, Poon RT, Fan ST, Cheung ST (correspondence). Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity. Cancer Immunology Research 2014; 2: 1209-1219.
  7. Cheung ST (correspondence), Cheung FY, Cheng CK, Wong NC, Fan ST. Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance. Gastroenterology 2011; 140: 344-355. Editorial Highlight.
  8. Ho JC, Ip YC, Cheung ST (correspondence), Lee YT, Chan KF, Wong SY, Fan ST. Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology 2008; 47: 1524-1532.

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