Department of Surgery, CUHK
INTRANET EVENTS NEWS


INTRODUCTION

The Division of Cardiothoracic Surgery is based at the Prince of Wales Hospital (PWH) an acute regional hospital as well as the teaching hospital associated with the Chinese University of Hong Kong. It performs over 700 major cases per year and provides complete services within the specialty for a population of approximately 2.2 million people excluding paediatric cardiac surgery and transplantation. There are 36 designated ward beds for Cardiothoracic patients in ward 7C (Level 7 New Block, PWH) and exclusive use of 6 high-dependency beds. Full private facilities are also available. As a teaching hospital, the Division contributes to the teaching and training of medical students, basic and higher surgical trainees and Overseas Fellows.

TEAM  VISION

To provide world-class service and to lead in the treatment of Cardiac, Thoracic and Aortic diseases.

TEAM  MISSIONS

  1. To advance education, training and succession in the field of Cardiac, Thoracic and Aortic interventions
  2. To provide quality-driven and outcome-monitored care to our patients
  3. To develop innovative and state-of-the-art researches as well as evidence-based medicine through National and International collaborations

SERVICES

We provide clinical services for both cardiac and thoracic pathologies.

We have established a centre of excellence in cardiac and aortic surgery, internationally recognised for pioneering minimally invasive techniques and mastering the most demanding re-operative procedures, which constitute 12% of our substantial surgical volume. Our elective coronary revascularisation mortality has remained below 1% for ten consecutive years—a benchmark of surgical precision sustained across a decade.

Our aortic root enlargement and mitral valve programmes have ascended to international prominence, delivering superior short- and mid-term outcomes that set the standard for the field. The aortic surgery division operates through a fully integrated, multidisciplinary consortium of interventional radiology, vascular surgery, cardiology, and anaesthesia, offering comprehensive therapeutic solutions for the most complex aortic pathologies.

Since 2007, we have advanced thoracic aortic care through endovascular innovation, accelerated by the inauguration of a state-of-the-art hybrid operating theatre in 2013. Our open aortic capabilities span the complete anatomical spectrum—from root and arch to descending and thoracoabdominal reconstruction—with outcomes that rank among the foremost in the discipline.

Our total arch replacement and frozen elephant trunk programme has drawn more than thirty international observers over the past decade, affirming our position as a global destination for advanced aortic training and knowledge exchange.

The thoracic side of our division provides world-class service in areas of minimally invasive video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery for all thoracic conditions of the lung, mediastinum and chest wall.

In particular, our team is well known in the region for bronchoscopic and airway surgery, minimally invasive and bronchoscopic treatment for emphysema, and chest wall reconstruction. Since introducing single port (uniportal) VATS lobectomy to Hong Kong in 2012, we have become a centre of excellence and training for local and regional surgeons, organizing numerous courses including the Asian Single Port VATS symposium, and hosting more than 30 observers and fellows.

In the past decade, the thoracic team has pioneered and mastered the used of hybrid operating theatre with advanced imaging capabilities to manage complex thoracic malignancies, localize small lung tumours, and allowing “one stop one shop” approach to managing lung cancers. Our work has driven the global trend of intra-operative imaging in thoracic surgery, as well as lung parenchyma sparing resections.

More recently, the division has become the world leader in navigation bronchoscopy and robotic-assisted bronchoscopy (RAB) for lung nodule diagnosis, localization and therapies. Having introduced bronchoscopic microwave ablation to Asia in 2019, and performed world's first RAB ablation in 2021, we have one of the largest experiences in the world of non-invasive ablative treatment approach to lung tumours, hosting international conferences, and training local doctors and visitors from across the globe. Our team also works closely with the internationally renowned lung cancer group from Department of Clinical Oncology to provide the best possible treatment plan and care for cancer patients.

ACHIEVEMENTS

ACHIEVEMENTS

RESEARCH  PROJECTS

The Division has ongoing clinical and basic science research interests which include:

CARDIAC & AORTIC:

  • Clinical outcomes monitoring and international bench marking of cardiac surgery outcomes
  • Radiomics and NGS study of genetically triggered thoracic aortic aneurysm and dissection
  • Valvular surgery, repair techniques and echo follow-up
  • Complex aortic surgery, neuroprotection and outcomes
  • Randomised Controlled Trial in Total Arch Replacement and Frozen Elephant Trunks in acute aortic dissection
  • 3-D printing guided cardiovascular Intervention
  • AI algorithm for screening for Thoracic Aortic Dissection, AMI and Acute Pulmonary Embolism (HMRF grant)
  • Deep learning enabled multi-modality automatic measurement, classification and risk prediction of various aortic conditions
  • Mitochondrial function in ischaemic reperfusion injury (GRF grant)
  • Role of iPSC-ECs in "Bio-coronary Bypass": A Project in Collaboration with NutrigeneAI

THORACIC
  • Molecular biology of lung cancer
    • T Cell Origin for Effective Solid Tumor Immunotherapy From Mechanistic Discovery to Clinical Validation
    • Histopathology-Based Machine Learning Approach
    • Development of a Novel Anticancer T cell origin for effective solid cancer immunotherapy
  • AI guided lung cancer screening for high-risk never smokers
  • Hybrid operating room navigation bronchoscopy treatment of lung cancer
  • Novel endoscope and robotic technologies for thoracic surgery
    • Novel AI assisted robotic multimodal bronchoscope
    • Intelligent robotic multi-modal imaging guiding transbronchial ablation of lung nodules
    • Thoracic Surgery by SHURUI Single-Port Surgical Robot: A Prospective Single Centre Study
    • Compliant ultra-reconfigurable robotic continuum by stiffness reprogramming to augment dexterous endoluminal contact-sensitive procedures
    • Navigation and Control of Robotic Bronchoscopy for Lung Nodule Biopsy in Dynamic Environments
    • Robotic Endobronchial Multi-modal Biopsy of Pulmonary Nodules
    • Intelligent Magnetic Anchored and Guided Endoscope with Surgeon Preference Embedded Autonomous View Control
  • Transbronchial Therapies in the Treatment of Pulmonary Malignancies
    • Survival, Immune Activation, and Functional Preservation Between Robotic-assisted / Image Guided Electromagnetic Navigation Bronchoscopic Therapies and Surgery in Stage IA NSCLC
    • Comparing navigation bronchoscopy-guided microwave ablation versus stereotactic body radiotherapy for medically inoperable or surgery-declining early-stage non-small cell lung cancer
    • Targetted Ablation and Resection Study with Galvanize Aliya EX Pulsed Electric Field (PEF) Technology. TARGET study
    • Clinical Trial Evaluating Navigational Bronchoscopy System and Bronchoscope and Accessories in Combination with Cryoablation therapy Device for the Treatment of Lung Malignancies
    • Confirmation of accuracy of the tool-in-lesion technology (TiLT) of the Galaxy System with integrated TOMO technology in human subjects to bronchoscopically biopsy small peripheral pulmonary nodules: TiLT study
  • Organoid, Aptamer and Nanoparticle use for the management of thoracic diseases
    • Construction of lung cancer organoid using fine needle aspirate or trucut biopsy
    • Spherical Nucleic Acid Nanostructures for Alleviating Chronic Pulmonary Disease
    • Repurposing Clopidogrel for Pneumoconiosis-induced Pulmonary Fibrosis by Targeting Macrophage-Myofibroblast Transition (MMT).

PEOPLE
Academic Staff
Professor WONG Hung Leung Randolph Professor
Professor NG Sze Hang Calvin Environmental Foundation Professor of Thoracic Surgery
HA Staff
Dr WAN Yuk Pui Innes Consultant
Dr KWOK Wai Ting Micky Consultant
Dr LAU Wing Hung Rainbow Consultant
Dr FUJIKAWA Takuya Consultant
Dr CHOW Chi Ying Simon Associate Consultant
Dr HO Yan Kit Jacky Associate Consultant
Dr CHAN Wing Yan Joyce Associate Consultant
Dr LIM Kevin Resident
Dr CHANG Tsz Ching Aliss Resident
Dr SIU Chi Hin Ivan Resident
Dr CHAN Hui Wah Clarence Resident
Dr HUNG Kai Fung Joshua Resident
Dr LUM Tak Wai Ray Resident
Dr CHAN Yvonne Yuet Yan Resident
Dr SOON Justin Rui Zhe Resident
Dr WAN Ho Ching Matthew Resident
Dr TANG Michael Pok Man Resident
Research Staff
Ms NG HL Karen EO (Data Manager)
Ms LO MK Eunice Research Assistant
Ms CHAN CS Junko Research Assistant
Mr LI Yulong Research Assistant
LIU Xinxin Research Assistant (EF)
Admin Staff
Ms CHONG Wing Sang Emily Project Co-ordinator II
Ms SZE Nok Wan Wanny Personal Secretary II

VIDEOS

Single Port VATS Vasoview Sympathectomy

Single Port VATS Hookwire Guided Wedge Resection

Single Port VATS Lobectomy

Single Port VATS Pneumonectomy

SELECTED PUBLICATIONS

CARDIAC & AORTIC

  • Hou Y, Ho CK, Lai B, Liu J, Li L, Lin J, Qu H, Wong RHL, Nie Y, Ding Q, Zhou B, Lui KO.
    CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes.
    Circulation. 2025 Dec 9;152(23):1634-1656. doi:10.1161/CIRCULATIONAHA.125.073890. Epub 2025 Nov 18.
  • Lee CP, Ng KH, Choi GY, Wong WT, Wong HMK, Ho KM, Ling L, Wong RH.
    Performance of Cleveland, Mehta, and Simplified Renal Index scores for predicting dialysis-requiring acute kidney injury after aortic vs. non-aortic cardiac surgery (2006-2023, 6160 patients).
    Ren Fail 2025 Dec; 47. 2592437. doi: 10.1080/0886022X.2025.2592437. Epub 2025 Nov 26.
  • Chan CH, Chow SC, Chang AT, Lai LM, Wah IY, Wong RH.
    Emergency Bentall procedure for acute type A aortic dissection in a patient with pre-term twin pregnancy.
    Ann Thorac Surg. 2025 Jun 2:S0003-4975(25)00482-5. doi:10.1016/j.athoracsur.2025.05.015
  • Wong HMK, Wong WT, Liu X, Au SSW, Wong RHL.
    Intravenous methadone for perioperative acute and chronic pain management in Chinese adult cardiac surgical patients: A protocol for pilot randomized controlled trial.
    PLoS One. 2025 Jun 2;20(6):e0323820. doi: 10.1371/journal.pone.0323820. eCollection 2025.
  • Lo EMK, Chen S, Ng KHL, Wong RHL.
    Artificial intelligence-powered solutions for automated aortic diameter measurement in computed tomography: a narrative review.
    Ann Transl Med. 2024 Dec 24;12(6):116. doi: 10.21037/atm-24-171. Epub 2024 Dec 18
  • Tsagakis K, Kempfert J, Zierer A, Martens A, Dohle DS, Castiglioni A, Wong RH, Widenka K, Liakopoulos O, Borger MA, Oo AY, Holubec T, Luehr M, Legarra Calderón JJ, Grabenwöger M.
    E-vita OPEN NEO in the treatment of acute or chronic aortic pathologies: first interim results of the NEOS study.
    Eur J Cardiothorac Surg 2024 Jun 3;65(6):ezae206. doi: 10.1093/ejcts/ezae206.
  • Chow SC, Lim K, Lum TW, Ho JY, Wan S, Fujikawa T, Wong RH.
    Individualized treatment of type A intramural hematoma-upfront surgery is not always necessary.
    J Thorac Dis. 2024 Apr 30;16(4):2225-2235. doi: 10.21037/jtd-23-1837. Epub 2024 Apr 17.PMID: 38738232
  • Conen D, Ke Wang M, Popova E, Chan MTV, Landoni G, Cata JP, Reimer C, McLean SR, Srinathan SK, Reyes JCT, Grande AM, Tallada AG, Sessler DI, Fleischmann E, Kabon B, Voltolini L, Cruz P, Maziak DE, Gutiérrez-Soriano L, McIntyre WF, Tandon V, Martínez-Téllez E, Guerra-Londono JJ, DuMerton D, Wong RHL, McGuire AL, Kidane B, Roux DP, Shargall Y, Wells JR, Ofori SN, Vincent J, Xu L, Li Z, Eikelboom JW, Jolly SS, Healey JS, Devereaux PJ; COP-AF Investigators.
    Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial.
    Lancet 2023 Aug 25:S0140-6736(23)01689-6. doi: 10.1016/S0140-6736(23)01689-6.
  • Ho JY, Kim CH, Chow SCY, Kwok MWT, Lee H, Kim TH, Fujikawa T, Wong RH, Song SW.
    Initial Asian experience of the branched E-vita Open NEO in complex aortic pathologies.
    J Thorac Dis Feb 2023. doi: 10.21037/jtd-22-1055
  • Lim K, Ho YK, Chow SCY, Fujikawa T, Lee AP, Wong RH.
    Peri-procedural Trans-esophageal Echocardiographic sizing of the native let ventricular outflow tract during Edwards INTUITY valve implantation.
    Front Cardiovasc Med. 2021 Jul 15;8:690752. doi: 10.3389/fcvm.2021.690752
  • Lim K, Chow SC, Ho JY, Wan S, Underwood M, Wong RH.
    Hepatorenal Dysfunction predicts operative mortality after triple valve surgery: Utility of MELD-Na.
    J Card Surg 2021 June;. 16. doi:10.1111/jocs.15745
  • Wong RH, Yang F, Fujikawa T, Wong MC, Yu SC, Underwood MJ, Lee AP.
    Pocket-size Mobile Echocardiography screening for thoracic aortic aneurysm in hypertensive patients.
    Ann Thorac Surg 2021 May. Volume 111, Issue 5, 1554-1559 doi:10.1016/j.athoracsur.2020.07.018
  • Wong RH, Ho JY, Bashir M, Jakob H.
    First-in-man implantation of Evita Open Neo in Hong Kong.
    CTSNet 2020. doi:10.25373/ctsnet.13373762.v1
  • Ho JY, Chow SC, Fujikawa T, Wong RH.
    Total aortic arch replacement and frozen elephant trunk.
    Sem Thorac Cardiovasc Surg. Nov 2020. doi:10.1053/j.semtcvs.2020.11.016
  • Ho JY, Chow SC, Fujikawa T, Wong RH.
    Surgical ventricular restoration with double patch postinfarction ventricular septal rupture repair.
    Int Cardiovasc Thorac Surg 2020 Nov, Vol31(5); 751. doi. 10.1093/icvts/ivaa181
  • Fujikawa T, Chow SCY, Chang ATC, Wong RHL.
    Open descending aortic replacement in a patient with a fractured Djumbodis™ dissection system.
    Eur J Cardiothorac Surg. 2020 Jul 1;58(1):199-201. doi: 10.1093/ejcts/ezz367
  • Chow SC, Wong RH, Lakhani I, Wong MV, Tse G, Yu PS, Ho JY, Fujikawa T, Underwood MJ.
    Management of acute type A intramural hematoma: Upfront surgery or individualized approach? A retrospective analysis and meta-analysis.
    J Thorac Dis. 2020 Mar;12(3):680-689. doi: 10.21037/jtd.2019.12.109.
  • Ho JY, Chan JY, Chow SC, Yu PS, Kwok MW, Cheung GS, Wong RH.
    Application of Cerebral Protection System in open mitral replacement with extensive calcified left atrial thrombus.
    Innovations. 2020 Jan/Feb;15(1):85-87. doi: 10.1177/1556984519892242
  • Fan Yiting, Wong RH, Lee AP.
    Three-dimensional printing in structural heart disease and intervention.
    Ann Transl Med. 2019 Oct; 7(20):579. doi: 10.21037/atm.2019.09.73.
  • Fujikawa T, Ho JYK, Wong HMK, Wong RHL.
    Open descending aortic replacement after Thoraflex™ hybrid graft implantation.
    Eur J Cardiothorac Surg. 2019 Sep 1;56(3):612-614. doi: 10.1093/ejcts/ezy481
  • Fujikawa T, Yamamoto S, Oshima S, Ozaki K, Shimamura J, Asada H, Wong RH.
    Open Surgery for Descending Thoracic Aorta in an Endovascular Era.
    J Thorac Cardiovasc Surg. 2019 Jun;157(6):2168-2174. doi: 10.1016/j.jtcvs.2018.08.094
  • Zhang J, Sheng J, Dong L, Xu Y, Yu L, Liu Y, Huang XR, Wan S, Lan HY, Wang HS.
    Cardiomyocyte-specific loss of RMP causes myocardial dysfunction and heart failure.
    doi:10.1093/cvr/cvy307
  • Zhang J, Yu LM, Xu YL, Liu Y, Li Z, Xue XD, Wan S, Wang HS.
    Long noncoding RNA upregulated in hypothermia treated cardiomyocytes protects against myocardial infarction through improving mitochondrial function.
    doi:10.1016/j.ijcard.2017.12.097
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang YH, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak K, Tong KK, Kwan KM, Wang NP, Chiu JJ, Zhu Y, Huang Y.
    Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.
    doi:10.1038/nature20602

THORACIC
  • Arman Sarshoghi, Arash Sarshoghi, Maxime Tetu, Calvin Ng, Lonny Yarmus, Patrick Bourgouin, Stephen Solomon, Felix Herth, Moishe Liberman.
    Cryoablation Protocols for Primary and Metastatic Lung Tumors: A Systematic Review and Meta-analysis Evaluating Effectiveness and Safety of Percutaneous Cryoablation of Pulmonary Tumors.
    J Vasc Interventional Radiology 2026 Jan;37(1):107871 doi: 10.1016/j.jvir.2025.10.004
  • Wei Liu, Aliss T.C. Chang, Joyce W.Y. Chan, Rainbow W.H. Lau, Tony S.K. Mok, Calvin S.H. Ng.
    Robotic-Assisted and Electromagnetic Navigation Bronchoscopy for Multi-focal Lung Cancer: A narrative review.
    Translational Lung Cancer Research 2025 Nov;14(11):5159-5180. doi: 10.21037/tlcr-2025-943
  • Shaorui Liu, Cecilia Ka Wing Chan, Yuan He, Leo Kit Cheung Lee, Zengbing Lu, Aixuan Li, Xiao Yu Tian, Man Nin Chan, Chun-Kwok Wong, John Anthony Rudd, Calvin Sze-Hang Ng, Chung Hang Jonathan Choi.
    An inhalable Spike–conjugated gold nanoparticle for treating acute lung inflammation.
    Advanced Functional Materials 2025 Nov; e15906 [on line 11-2025] doi: 10.1002/adfm.202515906
  • Jiawei Chen, Zhongqiao Mo, Hongsheng Deng, Calvin S. H. Ng, Zeyong Zhang, Shuben Li, Jianxing He.
    A case series of nonintubated robotic-assisted bronchoscopy: a feasible alternative to intubated techniques.
    Transl Lung Cancer Res. 2025 Sept;14(9):4051-56. doi: 10.21037/tlcr-2025-169
  • Zoey Zeyuan Ji, Max Kam-Kwan Chan, Philip Chiu-Tsun Tang, Calvin Sze-Hang Ng, Chunjie Li, Dongmei Zhang, David J. Nikolic-Paterson, Ka-Fai To, Xiaohua Jiang, Patrick Ming-Kuen Tang.
    Tumor innervation: from cancer bystander to emerging therapeutic target for cancer.
    Int J Mol Sci 2025 Sept;26:9257. doi:10.3390/ijms26189257
  • Jane Siu-fan Li, Zoey Zeyuan Ji, Aaron Qi Zhang, Calvin Sze-Hang Ng, Guibin Qiao, Dongmei Zhang, Chunjie Li, Qing Zhang, Ka Fai To, Patrick Ming-Kuen Tang.
    Tumor single-cell bioinformatics: from immune profiling to molecular dynamics.
    Journal of Cellular and Molecular Medicine. Sept 2025; 29:e70783. doi:10.1111/jcmm.70783
  • Jay M. Lee, Jean-Louis Pujol, Jun Zhang, Oleg Leonov, Masahiro Tsuboi, Edward S. Kim, Calvin Ng, Nicolas Moreno-Mata, Amy Cummings, Ilhan Hacibekiroglu, Abidin Sehitogullari, Nirmal Veeramachaneni, Cathy Spillane, Jiawei Duan, Claudia Bossen, Alexander Savchenko, Chiara Lobetti-Bodoni, Tony Mok, Pilar Garrido.
    CANOPY-N: A Phase 2 study of canakinumab or pembrolizumab, alone or in combination, as neoadjuvant therapy in patients with resectable, Stage IB–IIIA NSCLC.
    JTO Clinical and Research Reports (JTO CRR). 2025 Aug; 6(8):100859. doi:10.1016/j.jtocrr.2025.100859
  • Xiangyang Yu, Xiaoxing Ye, Mengqi Zhang, Wenting Huang, Calvin SH Ng, Zhentao Yu, Kai Ma.
    First case report of immune checkpoint inhibitor therapy to treat secretory carcinoma.
    Therapeutic Advances in Medical Oncology. 2025 Jul 29:17:17588359251357520. doi: 10.1177/17588359251357520
  • Chang ATC, Chan JWY, Siu ICH, Lau RWH, Chu CM, Mok TSK, Ng CSH.
    Hybrid treatment of multifocal lung malignancy by concomitant transbronchial microwave ablation with same session lung resection and post lung resection ablation.
    Interdiscip Cardiovasc Thorac Surg 2025 Jul 3;40(7):ivaf152. doi: 10.1093/icvts/ivaf152 (IF 1.7)
  • Jimenez M, Flandes J, van der Heijden EHFM, Ng CSH, Iding JS, Garcia-Hierro JF, Recalde-Zamacona B, Verhoeven RLJ, Lau RWH, Moreno-Gonzalez A, Hatton BA, Seshaiah P, Plentl MB, Krimsky WS.
    Safety and Feasibility of Pulsed Electric Field (PEF) Ablation for Early-Stage Non-Small Cell Lung Cancer (NSCLC) Prior to Surgical Resection.
    J Surg Oncol. Jun 2025;131(8):1529-1542. doi: 10.1002/jso.28110
  • Laeseke P, Ng C, Ferko N, Naghi A, Wright G, Di Wang, Laidlaw A, Kalsekar I, Laxmanan B, Ghosh SK, Zhou M, Szapary P, Pritchett M.
    Stereotactic body radiation therapy and thermal ablation for treatment of patients with pulmonary metastases: a systematic literature review and meta-analysis.
    BMC Pulm Med 2025 Apr;25(1):188. doi:10.1016/j.lungcan.2023.107259
  • Wenjie Luo, Mingjing Xu, Nathalie Wong, Calvin SH Ng.
    Alternative Splicing in Lung Adenocarcinoma: from Bench to Bedside.
    Cancers 2025 Apr, 17(8), 1329; doi:10.3390/cancers17081329
  • Stephanie P.L. Saw, Wen-Zhao Zhong, Rui Fu, Molly S.C. Li, Yasushi Goto, Stephen B. Fox, Yasushi Yatabe, Boon-Hean Ong, Calvin S.H. Ng, David D.W. Lee, Pham Cam Phuong, In Kyu Park, James C.H. Yang, Masahiro Tsuboi, Lye Mun Tho, Thomas John, Hsao-Hsun Hsu, Daniel S.W. Tan, Tony S.K. Mok, Thanyanan Reungwetwattana, Navneet Singh.
    Asian Thoracic Oncology Research Group expert consensus statement on the peri-operative management of non-small cell lung cancer.
    Lung Cancer 2025 Feb:200:108076. doi: 10.1016/j.lungcan.2024.108076
  • Chan JWY, Ng CSH.
    Transbronchial Ablation for Lung Cancers – Ready for Prime Time?
    Respirology 2025 Jan;30(1):16–7. doi:10.1111/resp.14850
  • Li Jixiu, Zhang Tao, Cheng Truman, Li Yehui, Huang Yisen, Ng Sze Hang, Chiu Philip Wai-yan, Li Zheng.
    Design, Analysis, and Kinematic Framework of a Long-range Magnetic Anchored and Guided Endoscope.
    IEEE/ASME Transactions on Mechatronics (TMECH) 2024 Dec;29(6):4228-39. doi: 10.1109/TMECH.2024.3368611
  • Alessandro Brunelli, Mara B Antonoff, Rene H Petersen, Brendon M Stiles, Dennis A Wigle, & Collaborators (Calvin S.H. Ng).
    Surgeon preferences for self-treatment in locally advanced non–small cell lung cancer: Would we practice what we preach?
    Eur J Cardiovasc Thorac Surg 14 Nov 2024;66(5): ezae344, doi:10.1093/ejcts/ezae344
  • Chao Xu, Tinghua Zhang, Syeda Aimen Abbasi, Peng Liu, Bryan Yan, Sze Hang Calvin Ng, Wu Yuan.
    Ultrathin visible-light OCT endomicroscopy for in vivo ultrahigh-resolution neuroimaging in deep brain.
    APL Photonics. Nov 2024;9(11):110804. doi: 10.1063/5.0221282
  • Luca Bertolaccini, Alessandro Brunelli, Clemens Aigner, Firas Abu Akar, Georges Decker, Wentao Fang, József Furák, Mahmoud Ismail, Marcelo Jiménez, Andreas Kirschbaum, Marko Kostic, Marco Lucchi, Shehab Mohamed, Sudish C. Murthy, Calvin S.H. Ng, Heribert Ortlieb, Nuria Novoa, Elena Prisciandaro, Lorenzo Spaggiari, Paula A. Ugalde, Francesco Zaraca.
    Optimal Planning and Management Strategies in Minimally Invasive Lung Segmentectomies: An International Delphi Consensus Report.
    Eur J Cardiothorac Surg, Oct 2024;66(4):ezae351. doi:10.1093/ejcts/ezae351
  • Zi-Ming Wang, Wen-Qiang Zhang, Dania Nachira, Wu Jun, Diego Gonzalez-Rivas, Harun Badakhshi, Mahmoud Ismail, Calvin S.H. Ng, Chen-Lu Yang, Pascal A Thomas, De-Ping Zhao.
    Effect of laterality on the postoperative survival of non-small cell lung cancer patients undergoing pneumonectomy.
    Transl Lung Cancer Res (TLCR) 2024 Sept 30;13(9):2411-2433. doi: 10.21037/tlcr-24
  • Tinghua Zhang, Sishen Yuan, Chao Xu, Peng Liu, Hing-Chiu Chang, Calvin S.H. Ng, Hongliang Ren, Wu Yuan.
    PneumaOCT: pneumatic optical coherence tomography endoscopy for targeted distortion-free imaging in tortuous and narrow internal lumens.
    Sci Adv. 2024 Aug; 10(35):eadp3145. doi: 10.1126/sciadv.adp3145
  • Inge Nicole Wijma, Roberto Fernando Casal, George Cheng, Paul F Einsiedel, Alberto Fantin, David J Hall, Felix J.F. Herth, Calvin S.H. Ng, Michael A. Pritchett, Pallav L Shah, Daniel P Steinfort, Rocco Trisolini, Roel L.J. Verhoeven, Erik H.F.M. van der Heijden.
    Radiation Principles, Protection and Reporting for Interventional Pulmonology. A World Association of Bronchology and Interventional Pulmonology (WABIP) White Paper Endorsed by European and American Association for Bronchology and Interventional Pulmonology (EABIP).
    Respiration 2024 Jul;103(11):707–722. doi: 10.1159/000540102
  • Chang ATC, Chan JWY, Siu ICH, Lau RWH, Ng CSH.
    Safety and Feasibility of transbronchial microwave ablation for subpleural lung nodules.
    Asian Cardiovascular and Thoracic Annals. 2024 June;32(5):294-305. doi:10.1177/02184923241228323
  • Lau KKW, Lau RWH, Baranowski R, Krzykowski J, Ng CSH.
    Transbronchial microwave ablation of peripheral lung tumours: The NAVABLATE study.
    Journal of Bronchology and Interventional Pulmonology 2024 Apr;31(2):165-174. doi: 10.1097/LBR.0000000000000950
  • Mirza M, Shrivastava A, Matthews C, Leighl N, Ng CSH, Planchard D, Popat S, Rotow J, Smit EF, Soo R, Tsuboi M, Yang F, Stiles B, Grohe C, Wu Y-L.
    Treatment decision for recurrences in non-small cell lung cancer during or after adjuvant osimertinib: an international Delphi consensus report.
    Front. Oncol. 2024 Jan;13:1330468. doi: 10.3389/fonc.2023.1330468
  • Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Jeff Yat-Fai Chung, Alex Siu-Wing Chan, Dongmei Zhang, Chunjie Li, Kam-Tong Leung, Calvin Sze-Hang Ng, Yi Wu, Ka-Fai To, Hui-Yao Lan. Patrick Ming-Kuen Tang.
    Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in non-small-cell Lung Carcinoma.
    Adv. Sci. 2024 Jan;11: 2470006. doi:10.1002/advs.202470006
  • Chao Xu, Xin Guan, Syeda Aimen Abbasi, Neng Xia, To Ngai, Li Zhang, Ho-pui Ho, Sze Hang Calvin Ng, Wu Yuan.
    Liquid-shaped microlens for scalable production of ultrahigh-resolution optical coherence tomography microendoscope.
    Communications Engineering. Commun Eng 3, 1 (2024). Acknowledge RGC GRF No. 14203821. doi: 10.1038/s44172-023-00157-1
  • Joyce W.Y. Chan, Rainbow W.H. Lau, Aliss T.C Chang, Ivan C.H. Siu, Cheuk Man Chu, Tony S.K. Mok, Calvin S.H. Ng.
    Concomitant Electromagnetic Navigation Transbronchial Microwave Ablation of Multiple Lung Nodules is Safe, Time-saving and Cost-effective.
    JTCVS Techniques 2023 Dec;22:265-272 doi:10.1016/j.lungcan.2023.107259 doi:10.1016/j.xjtc.2023.07.027
  • Deng Hongsheng, Zhou Juan, Chen Hualin, Cai Xiuyu, Zhong Ran, Li Feng, Cheng Bo, Li Caichen, Jia Qingzhu, Zhou Caicun, Petersen René Horsleben, Rocco Gaetano, Brunelli Alex, Ng Calvin SH, D’Amico Thomas A., Su Chunxia, He Jianxing, Liang Wenhua, Zhu Bo, on behalf of the AME Thoracic Surgery Collaborative Group.
    Impact of lymphadenectomy extent on immunotherapy efficacy in post-resectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study.
    Int J Surg 2023 Sep 27;110(1):238–52. doi: 10.1097/JS9.0000000000000774
  • Paul Laeseke, Calvin Ng, Nicole Ferko, Andrada Naghi, George Wright, Yuxin Zhang, Alyshia Laidlaw, Iftekhar Kalsekar, Balaji Laxmanan, Sudip Ghosh, Meijia Zhou, Philippe Szapary, Michael Pritchett.
    Stereotactic body radiation therapy and thermal ablation for treatment of NSCLC: a systematic literature review and meta-analysis.
    Lung Cancer 2023 Jun;182:107259. doi:10.1016/j.lungcan.2023.107259 (IF 6.08)
  • Maxwell CM, Ng CSH, Fernando HC.
    Stereotactic Body radiation therapy versus ablation versus surgery for early-stage lung cancer in high-risk patient. Controversies in Thoracic Surgery.
    Thorac Surg Clinics. Ed. Schumacher/ Griffin. 2023 May;33(2):179-187. doi:10.1016/j.thorsurg.2023.01.003
  • Tamim Ahmad Haidari, Leizl Joy Nayahangan, Flemming Bjerrum, Henrik Jessen Hansen, Lars Konge, Gilbert Massard, Hasan Fevzi Batirel, Nuria Maria Novoa, Richard Stephen Milton, René Horsleben Petersen and the Delphi participants (Alessandro Brunelli, Enrico Ruffini, Herbert Decaluwe, Hermien Schreurs, Zalan Szanto, David Gerard Healy, Pierre-Emmanuel Falcoz, Willem-Hans Steup, Fernando Vannucci, Masayuki Chida, Christopher Cao, Wentao Fang, Tadasu Kohno, Dominique Gossot, Tim Batchelor, Kelvin Lau, Jean-Marc Baste, Brendon Matthew Stiles, Ferenc Renyi-Vamos, Youri Sokolow, Giuseppe Cardillo, Morten Bendixen, Thomas Decker Christensen, Michael Stenger, and Calvin S.H. Ng).
    Consensus on technical procedures for simulation-based training in thoracic surgery: An international needs assessment.
    Eur J Cardiothorac Surg 2023 Apr; Vol 63, Issue 4, ezad058. doi:10.1093/ejcts/ezad058
  • Ng CSH, Ong BH, Chao YK, Wright GM, Sekine Y, Wong IYH, Hao Z, Zhang G, Chaturvedi H, Thammineedi SR, Law SYK, Kim HK.
    The use of indocyanine green fluorescence imaging in thoracic and esophageal surgery.
    Ann Thorac Surg 2023 Apr;115(4):1068-76. doi: 10.1016/j.athoracsur.2022.06.061
  • Jeff Yat-Fai Chung, Philip Chiu Tsun Tang, Max Kam Kwan Chan, Xiao-Ru Huang, Vivian Weiwei Xue, Calvin Ng, Dongmei Zhang, Kam Tong Leung, Chun Kwok Wong, Tin-Lap Lee, Eric Lam, Ka-Fai To, Hui-Yao Lan, and Patrick Ming-Kuen Tang.
    Smad3 is Essential for Polarization of Tumor-Associated Neutrophils in Non-small cell lung carcinoma.
    Nature Communications 2023 Mar;14:1794. doi.org/10.1038/s41467-023-37515-8
  • Joyce W.Y. Chan, Ivan C.H. Siu, Aliss T.C. Chang, Molly S.C. Li, Rainbow W.H. Lau, Tony S.K. Mok, Calvin S.H. Ng.
    Transbronchial Techniques for Lung Cancer Treatment: Where Are We Now?
    Cancers 2023 Feb 8;15(4), 1068. doi.org/10.3390/cancers15041068
  • Jia Peng, Shucai Yang, Calvin S.H. Ng#, George G Chen# (#corresponding authors).
    The Role of FOXP3 in Non-small Cell Lung Cancer and its Therapeutic Potentials.
    Pharmacol Ther 2023 Jan; 241: 108333. doi:10.1016/j.pharmthera.2022.108333
  • Philip Chiu-Tsun Tang , Jeff Yat-Fai Chung , Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze-Hang Ng , Eric W.F. Lam , Yi-Ping Ho, Ka Fai To , Kam Tong Leung , Xiaohua Jiang, Ho Ko, Tin-Lap Lee, Hui Yao Lan, Patrick Ming-Kuen Tang.
    Single-cell RNA-sequencing Uncovers a Neuron-like Macrophage Subset Associated with Cancer Pain.
    Science Advances 2022 Oct 7;8(40): eabn5535. doi: 10.1126/sciadv.abn5535
  • Chan JWY, Chang ATC, Yu PSY, Lau RWH, Ng CSH.
    Robotic Assisted-Bronchoscopy with Cone-Beam CT ICG Dye Marking for Lung Nodule Localization: Experience Beyond USA.
    Frontiers in Surgery 2022 Jun 28;9:943531. doi:10.3389/fsurg.2022.943531
  • Jun Liu, Hengrui Liang, Fei Cui, Hui Liu, Chengchu Zhu, Wenhua Liang, Jianxing He, The International Tubeless-VATS Collaboration (ITVS) [Jun Liu, Hengrui Liang, Fei Cui, Hui Liu, Chengchu Zhu, Tianyang Dai, Kaican Cai, Zhifeng Zhang, Chao Cheng, Kun Qiao, Xiang Liu, Guangsuo Wang., Shun Xu, Wei Wang, Qinglong Dong, Lixia Liang, Hanyu Yang, Yingfen Li, Shunjun Jiang, Jiang Jin, Jianfei Shen, Jinfeng Ding, Kaiming He, Yulin Liu, Jing Ye, Siyang Feng, Haofei Wang, Jiang Yu, Haoda Huang, Huangkai Zhang, Zhenguo Liu, Xia Feng, Zhaohua Xia, Mingfei Ma, Zhongxin Duan, Tonghai Huang, Yali Li, Qiming Shen, Wenfei Tan, Hong Ma, Calvin S.H. Ng, Diego González-Rivas, Eugenio Pompeo, Erlin Daley, Raja M. Flores, Yaron Shargall, Mahmoud Ismail, Keng-Leong Ang, Vincenzo Ambrogi, Ahmed Elkhouly, Wenhua Liang, Jianxing He.
    Spontaneous versus Mechanical Ventilation during Video-Assisted Thoracoscopic Surgery for Spontaneous Pneumothorax: A Randomized Trial.
    J Thorac Cardiovasc Surg 2022 May;163(5):1702-1714.e7. doi:10.1016/j.jtcvs.2021.01.093
  • Zi-Ming Wang, Feng Li, Lara Sarigül, Dania Nachira, Diego Gonzalez-Rivas, Harun Badakhshi, Jens-C Rückert, Calvin S H Ng, Mahmoud Ismail.
    A predictive model of lymph node metastasis for thymic epithelial tumors.
    Eur J Cardio-Thorac Surg 2022 Apr 11;ezac210. doi: 10.1093/ejcts/ezac210
  • Francesco Zaraca, Alessandro Brunelli, Marco Damiano Pipitone, Amr Abdellateef, Firas Abu Akar, Florian Augustin, Tim Batchelor, Alessandro Bertani, Roberto Crisci, Thomas D’Amico, Xavier Benoit D'Journo, Andrea Droghetti, Wentao Fang, Alessandro Gonfiotti, Miroslav Janík, Marcelo Jiménez, Andreas Kirschbaum, Marko Kostic, Richard Lazzaro, Marco Lucchi, Alessandro Marra, Sudish Murthy, Calvin S.H. Ng, Dania Nachira, Alessandro Pardolesi, Reinhold Perkmann, René Horsleben Petersen, Vadim Pischik, Michele Dario Russo, Isabelle Schmitt-Opitz, Lorenzo Spaggiari, Paula A. Ugalde, Fernando Vannucci, Giulia Veronesi, Luca Bertolaccini.
    A Delphi Consensus Report from The PALAS Study Group (Prolonged Air Leak: A Survey) on Prevention and Management of Postoperative Air Leaks After Minimally Invasive Anatomical Resections.
    Eur J Cardiothorac Surg 2022 Apr 4;ezac211. doi: 10.1093/ejcts/ezac211
  • Hongsheng Deng, Jun Liu, Xiuyu Cai, Jiawei Chen, Rocco Gaetano, René Horsleben Petersen, Alex Brunelli, Calvin S H Ng, Thomas A D'Amico, Wenhua Liang, Jianxing He.
    Radical Minimally Invasive Surgery following Immuno-chemotherapy in Initially-unresectable Stage IIIB Non-small cell lung cancer.
    Ann Surg 2022 Mar;275(3):e600-e602. doi: 10.1097/SLA.0000000000005233
  • Chan JWY, Lau RWH, Chu CM, Ng CSH.
    Expanding the Scope of Electromagnetic Navigation Bronchoscopy-guided Transbronchial Biopsy and Ablation with Mobile 3D C-arm Machine Cios Spin® - Feasibility and Challenges.
    Transl Lung Cancer Res 2021 Oct;10(10):4043-4046. doi:10.21037/tlcr-21-619
  • Bin Zhou, Qiuyuan Li, Linlin Qin, Zhao Li, Kaiqi Jin, Jie Dai, Yuming Zhu, Yang Yang, Salma K. Jabbour, Alfredo Tartarone, Calvin S. H. Ng, Alfons Navarro, Cecilia Pompili, Gening Jiang.
    Octogenarians may benefit from stage-specific small cell lung cancer treatment.
    Transl Lung Cancer Res 2021 Oct;10(10):3973-3982. doi:10.21037/tlcr-21-839
  • Chan JWY, Lau RWH, Ngai JCL, Tsoi C, Chu CM, Mok TSK, Ng CSH.
    Transbronchial Microwave Ablation of Lung Nodules with Electromagnetic Navigation Bronchoscopy Guidance – A Novel Technique and Initial Experience with 30 Cases.
    Transl Lung Cancer Res 2021 Apr;10(4):1608-1622. doi:10.21037/tlcr-20-1231
  • Xiangyang Yu, Rusi Zhang, Mengqi Zhang, Yongbin Lin, Xuewen Zhang, Yingsheng Wen, Longjun Yang, Zirui Huang, Gongming Wang, Dechang Zhao, Michel Gonzalez, Jean-Marc Baste, Rene Horsleben Petersen, Calvin S.H. Ng, Alessandro Brunelli, Lie Zheng, Lanjun Zhang, written on behalf of the AME Thoracic Surgery Collaborative Group.
    Segmental resection is associated with decreased survival in patients with stage IA non-small cell lung cancer with a tumor size of 21 -30 mm.
    Transl Lung Cancer Res 2021 Feb;10(2):900-913. doi: 10.21037/tlcr-20-1217
  • Yu PSY, Chu CM, Lau RWH, Ng CSH.
    Hybrid Theatre Facilitates Lung-Preserving Multimodal Treatment for Multiple Pulmonary Metastases.
    Ann Thorac Surg 2020. doi: 10.1016/j.athoracsur.2020.05.098
  • Chan JWY, Lau RWH, Ng CSH.
    Electromagnetic Navigation Bronchoscopy Fiducial Marker Margin Identification plus Triple Dye for Complete Lung Nodule Resection.
    J Thorac Cardiovasc Surg Techniques 2020 Sept;3:P329-333. doi:10.1016/j.xjtc.2020.07.010
  • Ng CSH, Zhao Z, Long H, Lau RWH.
    Electromagnetic Navigation Bronchoscopy Triple Contrast Dye Marking for Lung Nodule Localization.
    Thorac Cardiovasc Surg 2020 Apr;68(3):253-255. doi: 10.1055/s-0038-1676964
  • Zang R, Shi JF, Lerut TE, Wang L, Liu CC, Brunelli A, Petersen RH, Ng CSH, Lim E, Gao S; AME Thoracic Surgery Collaborate Group.
    Ten-Year Trends of Clinicopathologic Features and Surgical Treatment of Lung Cancer in China.
    Ann Thorac Surg. 2020 Feb;109:389-395. doi:10.1016/j.athoracsur.2019.08.017
  • Bertolaccini L, Batirel H, Brunelli A, Gonzalez-Rivas D, Ismail M, Ucar AM, Ng CSH, Scarci M, Sihoe ADL, Ugalde PA, Abu Akar F, Bedetti B, Nadal SB, Brandolini J, Crucitti P, Enyedi A, Fernando HC, Furak J, Gallego-Poveda J, Galvez-Munos C, Hanke I, Janik M, Juhos P, Libretti L, Lucciarini P, Macrì P, Margaritora S, Mahoozi HR, Nachira D, Pardolesi A, Pischik V, Sagan D, Schreurs H, Sekhniaidze D, Tosi D, Turna A, Vannucci F, Zielinski M, Rocco G.
    Uniportal video-assisted thoracic surgery lobectomy: a consensus report from the Uniportal VATS Interest Group (UVIG) of the European Society of Thoracic Surgeons (ESTS).
    Eur J Cardiothorac Surg. 2019 Aug 1;56(2):224-229. doi: 10.1093/ejcts/ezz133
  • Chan AW, Chau SL, Tong JH, Chow C, Kwan JS, Chung LY, Lung RW, Tong CY, Tin EK, Law PP, Law WT, Ng CS, Wan IY, Mok TS, To KF.
    The landscape of actionable molecular alterations in immunomarker-defined large cell carcinoma of lung.
    J Thorac Oncol. 2019 Jul;14(7):1213-1222. doi: 10.1016/j.jtho.2019.03.021
  • Zhao Y, Wang W, Liang H, Jeffrey Yang CF, D'Amico T, Ng CSH, Liu CC, Petersen RH, Rocco G, Brunelli A, Liu J, He J, Huang W, Liang W, He J; AME Thoracic Surgery Collaborative Group.
    The Optimal Treatment for Stage IIIA-N2 Non-small-cell Lung Cancer: A Network Meta-analysis.
    Ann Thorac Surg 2019 Jun;107(6):1866-1875. doi:10.1016/j.athoracsur.2018.11.024
  • Ng CSH, MacDonald JK, Gilbert S, Khan AZ, Kim YT, Louie BE, Marshall MB, Sales dos Santos R, Scarci M, Shargall Y, Fernando HC.v Expert Consensus Statement on Optimal Approach to Lobectomy for Non-Small Cell Lung Cancer.
    Innovations 2019 Apr;14(2):87-89. doi:10.1177/1556984519837007
  • Ng CSH, MacDonald JK, Gilbert S, Khan AZ, Kim YT, Louie BE, Marshall MB, Sales dos Santos R, Scarci M, Shargall Y, Fernando HC.
    Optimal Approach to Lobectomy for Non-Small Cell Lung Cancer: Systemic Review and Meta-Analysis.
    Innovations 2019 Apr;14(2):90-116. doi:10.1177/1556984519837027
  • Zhang L, Wang L, Kadeer X, Zeyao L, Sun X, Sun W, She Y, Xie D, Li M, Zou L, Rocco G, Yang P, Chen C, Liu CC, Petersen RH, Ng CSH, Parrish S, Zhang YS, Giordano R, di Tommaso L; AME Thoracic Surgery Collaborative Group.
    Accuracy of a 3-Dimensionally Printed Navigational Template for Localizing Small Pulmonary Nodules: A Noninferiority Randomized Clinical Trial.
    JAMA Surg. 2019 Apr 1;154(4):295-303. doi: 10.1001/jamasurg.2018.4872
  • Zhao ZR, Lau RWH, Long H, Mok TSK, Chen GG, Underwood MJ, Ng CSH.
    Novel method for rapid identification of micropapillary or solid components in early-stage lung adenocarcinoma.
    J Thorac Cardiovasc Surg 2018 Dec; 156:2310-8. doi:10.1016/j.jtcvs.2018.07.054
  • Zhao ZR, Lau RWH, Ng CSH.
    Hybrid theatre and uniportal VATS: the perfect match for lung nodule localization.
    Thorac Surg Clin 2017 Nov;27(4):347-55. doi:10.1016/j.thorsurg.2017.06.003
  • Zhao ZR, Situ DR, Lau RWH, Mok TSK, Chen GG, Underwood MJ, Ng CSH.
    Comparison of segmentectomy and lobectomy in stage IA adenocarcinomas.
    J Thorac Oncol 2017 May;12(5):890-896. doi: 10.1016/j.jtho.2017.01.012
  • Liang WH, He JX, Shen YX, Shen JF, He QH, Zhang JR, Jiang GN, Wang Q, Liu LX, Gao SG, Liu DR, Wang Z, Zhu ZH, Ng CSH, Liu CC, Petersen RH, Rocco G, D’Amico T, Brunelli A, Chen HQ, Zhi XY, Liu B, Yang YX, Chen WS, Zhou Q, He JX.
    Impact of Examined Lymph Node Count on Precise Staging and Long-term Survival of Resected NSCLC: A Population Study of the U.S. SEER Database and a Chinese Multi-Institutional Registry.
    J Clin Oncol 2017 Apr 10;35(11):1162-1170. doi: 10.1200/JCO.2016.67.5140
  • Ng CSH, Zhao ZR, Lau RWH.
    Tailored Therapy for Stage I Non-small Cell Lung Cancer.
    J Clin Oncol 2017 Jan;35(3):268-270. doi: 10.1200/JCO.2016.70.4718
  • Dai CY, Shen JF, Ren YJ, Zhong SY, Zheng H, He JX, Xie D, Fei K, Liang WH, Jiang G, Yang P, Petersen RH, Ng CSH, Liu CC, Brunelli A, Chen C, He JX, written on behalf of the AME Thoracic Surgery Collaborative Group.
    Choice of surgical procedure for patients with NSCLC ≤1 cm or >1 to 2 cm among lobectomy, segmentectomy and wedge resection: A population-based study.
    J Clin Oncol 2016 Sept 10;34(26):3175-82. doi:10.1200/JCO.2015.64.6729
  • Ng CSH, Yu SCH, Lau RWH, Yim APC.
    Hybrid Dyna - CT Guided Electromagnetic Navigational Bronchoscopic Biopsy.
    Eur J Cardiothorac Surg 2016 Jan;48(S1):i87-88. doi: 10.1093/ejcts/ezv405



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